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Description
Largely elevated levels of circulating IGF-I but as a result of absence of proteolysis of IGFBP-5 and IGFBP-3, necessary for disruption of ternary complex formation, IGF-I bioactivity in serum is low and presumably tissue bioactivity of IGF-I (and IGF-II) is low
DSIP has been studied in humans since the early 1980s, with multiple double-blind placebo-controlled trials
[10]Li Z, Min D, et al

Campbell-McBride's book "Gut and Psychology Syndrome
There will be emphasis on the consequences accompanying these metabolic changes and current efforts to target this
