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Evaluation of neurotransmitters involved in the anxiolytic and panicolytic effect of the aqueous fraction of Paullinia cupana (guaran) in elevated T maze

Lasley, BL

Common (PN-related) Nausea Vomiting Mild fever or infusion discomfort Elevated BUN (from total nitrogen load) Hyperglycemia (PN carbohydrate component) Electrolyte abnormalities Proline-Specific Considerations Hyperprolinemia (rare without metabolic disorders) Symptoms may include: Neurologic changes Seizures (in genetic metabolic disorders) Cognitive alterations Amino-acid imbalance if hepatic metabolism impaired Severe (rare) Anaphylactoid reactions to amino-acid solutions Liver dysfunction with long-term high-dose PN Metabolic acidosis from improper PN formulation Refeeding syndrome (phosphate, potassium, magnesium shifts) Pregnancy & Breastfeeding Pregnancy Proline is a normal nutritional requirement and is safe when delivered as part of PN