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Further research has revealed that Esculin induces endoplasmic reticulum stress and promotes ferroptosis in colorectal cancer by modulating PERK through the eIF2/CHOP and Nrf2/HO- 1 cascade reactions [67]

Graphical abstract Similar content being viewed by others 1 Introduction to ROS Despite of significant progress in medical sciences, there are always challenges to mitigate the oxidative stress-mediated diseases via cellular and biological damages

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