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Due to their complexity, unclarified pathogenesis, progressive and severe nature, it is likely that a truly disease-modifying therapy for neurodegenerative diseases needs to regulate several pathological pathways simultaneously (Li et al., 2020)

These persulfides are further processed reductively 16-18 or oxidatively 19-21 depending on the sulfide homeostatic pathway the organism possesses, into less toxic sulfur species, which are eventually effluxed or assimilated

Apoptosis was assessed using the Annexin V-FITC/PI Apoptosis Kit (cat No

Disruption of the Mouse Mdr1a P-Glycoprotein Gene Leads to a Deficiency in the Blood-Brain Barrier and to Increased Sensitivity to Drugs

These findings suggest exploiting cellular metabolic plasticity to modulate T-cell metabolism and antitumor immune responses through glutamine blockade