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It also supports neurogenesis and protects nerve cells, which help repair and detoxify the brain

Tramontano A, Chothia C, Lesk AM: Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins

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Martin TA, Harrison G, Mansel RE, Jiang WG

Importantly, HO-1 can be targeted pharmacologically by interventions that seek its upregulation or enhancement of its various arms of action, via: (1) induction of HO-1 expression with drugs such as heme arginate, (2) administration of CO by inhalation or use of CO releasing molecules (CORM), and (3) administration of biliverdin/bilirubin or use of inhibitors of bilirubin conjugation that would result in increased bilirubin levels