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Hanefeld U, Cao L, Magner E

Another possible explanation is that LC works at the hypothalamic level

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( 10.1016/j.kint.2016.01.014) [DOI] [PubMed] [Google Scholar] 34

Although the histological criteria are not well defined, large nuclei with prominent nucleoli, brisk mitotic activity, and necrosis are worrisome signs of aggressive biological behavior
