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Possible explanations may include the stimulation of collagen creation by crosslinked HA filler, and up-regulation of elastin which helps keep skin supple

However, given the proposed molecular pathways and targets, it is of importance to focus on probable adverse effects resulting from its single or chronic administration before falling into complete admiration and considering the compound as a panacea effective for all conditions with a highly postulated safety profile

Journal of Biological Chemistry 262, 1987

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