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8 Discussion and conclusion Cerebral ischemia remains a major global health challenge due to its high rates of morbidity, mortality, and long-term neurological disability

For example, since CTLA-4 is present in the pituitary gland, patients treated with antiCTLA-4 often develop hypophysitis, an autoimmune disease of the pituitary gland, but this side effect is rare in patients treated with antiPD1

Kynurenic acid and its derivatives are able to modulate the adhesion and locomotion of brain endothelial cells

For example, atherosclerosis develops as a result of local intensification of endotheliosis in specific segments of large arteries, but at the stage of an unstable atherosclerotic plaque, acquires many features of classical productive inflammation [879]

The Nrf2 signaling pathway responds to oxidative stress by upregulation of antioxidants like glutathione (GSH) to compensate the stress insult and re-establish homeostasis