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Validation of target genes in secondary screenings A curated list of target genes (Supplementary Dataset 3), which emerged from the shRNA screen and subsequent GO analysis, was used for further validation with siRNAs selected from the Human Druggable Genome siRNA Library (Dharmacon)

Dogs/Cats - 0.25 to 0.5 mL

melanogaster with no reduction in fertility (Mason et al., 2018)

doi: 10.1111/1753-0407.13446

If mitochondria are not protected against OS insult, the organelles become irreversibly damaged through a process culminating with induction of a mitochondrial permeability transition (mPT) which is associated with the collapse of mitochondrial membrane () and colloid osmotic swelling of the matrix [46]
