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While the reaction of the therapeutic antibody seems relatively straightforward on the myeloma side (as MM cells are FcR-negative), more complex interactions occur with effector cells (FcR + ), where the antibody can engage both the Fab-binding site and one of the FcRs on the same cell ( Figure 3 ) (110)

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Vitamin B12 shuttles between methylcobalamin and cob(I)alamin states

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is essential for several critical bodily functions

Drugs you should not use with methotrexate Do not take these drugs with methotrexate