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When cocultured with PB mononuclear cells, these MenSCs presented increased expression of indoleamine 2,3-dioxygenase-1 and COX-2, as well as elevated secretion of proinflammatory cytokines such as IFN-, IL-10, and monocyte chemoattractant protein-1, suggesting that MenSCs may contribute to disease progression through immunomodulation and altered cellular behavior (Nikoo et al., 2014)

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6E, the Spearman correlation coefficient between TLR2 positive expression level and the proportion of apoptotic blasts was calculated ( R = 0.943, p = 0.017)

Studies have shown that crocin can improve the histopathological changes caused by doxorubicin (Razmaraii et al., 2016), and attenuated the cardiotoxicity induced by diazinon (Razavi et al., 2013)