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Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model

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This review highlights that the dominance of M2-like TAMs in the OC TME creates an environment that supports tumor survival, promotes angiogenesis, facilitates metastasis, and suppresses adaptive immune responses through the secretion of various pro-tumorigenic factors such as IL-10, TGF-, and VEGF