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In summary, the accumulation of TMAO will not only increase oxidative stress and endothelial cell damage and permeability but also lead to an increase endothelial-derived NOS expression ( Vascular Calcification: TMAO Activates the NLRP3 Inflammasome and NF-B Signaling Pathway in Vascular Smooth Muscle Cells (VSMCs) Vascular calcification (VC) is a phenomenon of disseminated deposition of mineral content within the medial layer of arteries

Kawada, T., et al

Then cellulose (3.0 g) and sodium periodate (6.0 g) were added into the flask and stirred at 35C for 3 h

& Whang, Y

The cell membrane can be thought of as a lipid-bilayer sphere