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Both COX isoforms are heterodimers, with each subunit of the dimer containing an epidermal growth domain, membrane-binding domain, and catalytic domain where the cyclooxygenase and peroxidase active sites are found on either side of the heme prosthetic group (Rouzer and Marnett, 2009)

Understanding such metabolic transitions and how to modulate them is essential for the optimization of differentiation processes to ensure safe iPSC-derived cell therapies

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