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Similarly, under pathogenic infection, MEKK1-MKK4-MPK3/6 is identified to function upstream of NADPH oxidase trigger H 2 O 2 production, and this, in turn, leads to the further activation of MPK3 and MPK6 [118]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 273.Leenaars C.H.C., Kouwenaar C., Stafleu F.R., Bleich A., Ritskes-Hoitinga M., De Vries R.B.-M., Meijboom F.L.B

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Like Hashimotos disease, its considered an autoimmune condition
