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Nutrients 2019;11(7):1483
For instance, in ovarian cancer, a study demonstrated that curcumin induced autophagy via the inhibition of the AKT/mTOR/p70S6K signaling pathway, enhanced light chain (LC)3B-I/II expression and increased autophagy related 3 and Beclin1 expression in a concentration-dependent manner (49)
When compared with the control, in both the studies authors found a significant decrease in GSH upon methylglyoxal treatment
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These associations were strengthened even after considering the potential confounders
