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Since GLP-1 production is assumed to remain intact in well-controlled diabetic patients and stimulates insulin release and lowers postprandial glycemia, several therapeutic approaches are being developed to increase GLP-1 action for treating diabetes mellitus [27]

Furthermore, an alteration in cell state and expression profile (i.e., increase in pro-inflammatory cytokines and nitric oxide) was observed in cultured BV-2 cells treated with a CB 1 R antagonist (Lou et al., 2018)

Therefore, a possible correlation between the rs1050450 variant and serum Hcy levels was hypothesized

Your liver produces it and it is present in almost every cell of your body