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For instance, depletion of plasmalogen PCs and PUFA-containing GPLs in LID suggests a role in increased membrane fluidity and oxidative vulnerability, whereas the imbalance in hydroxylated and non-hydroxylated sulfatides points to potential disruptions in myelin integrity and neuronal signalling

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FIGURE 2 3.1 Regulating gut microbiota and metabolites The available evidence indicates that UC is an increased immune response in the mucosal lining, which is triggered by an imbalance in particular gut bacteria

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The melatonin in circulation can travel to all tissues in the body and easily modulate activity of brain by crossing bloodbrain barrier