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Research indicates that up to 50% of individuals may require a customized, more frequent injection schedule (such as every 2 to 4 weeks) to remain completely free of symptoms [2]

For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative

2023 Dec 14;389(24):2221-2232

Additionally, researchers have speculated that AHK-Cu might influence the transition and duration of hair growth phases, particularly the anagen stage, although further confirmation is needed

Preclinical studies indicated that synthetic fragments corresponding to this domain could increase fat oxidation, affect adipocyte metabolism and reduce lipid deposition in models of obesity