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This difference could be due to the fact that DEM decreases both nuclear and cytosolic glutathione levels in opposition to BSO, which only decreases cytosolic glutathione as it is shown in figure 4C

Due to the involvement of vitamin B12 in many enzymatic processes, its deficiency results in the impaired function of many different organs and systems

doi: 10.1007/s00441-009-0751-8 36 BruewerMUtechMIvanovAIHopkinsAMParkosCANusratA

These multiple biomarkers could increase sensitivity and specificity in OSF diagnosis (Kaur et al., 2016)