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Disease or injury models can alter inflammation, metabolism, tissue vulnerability, mortality risk, and remodeling, which limits how broadly safety-related observations can be generalized

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40,41 It should also be noted that several well-controlled studies have demonstrated that the expression of the neuropeptide somatostatin, which is commonly coreleased by GABAergic interneurons, is reduced in postmortem brains of MDD patients in such regions as the amygdala and subgenual cingulate

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