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These drugs can elicit some side effects, including nausea, dizziness, xerostomia, constipation, drowsiness, mood disorders, blurred vision, and difficulties with focus and concentration [230]

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During strong autoimmune responses or central nervous system infections, immune cells like leukocytes, monocytes, and macrophages can cross the BBB using paracellular and transcellular routes[187]

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This creates an individualized optimization challenge: finding the lowest dose that produces satisfactory results while minimizing adverse effects

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