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In previous clinical trials for obesity, Tesofensine has been studied in varying dosages, typically starting with a lower dose and gradually increasing it to assess efficacy and tolerability during drug administration

A multicenter, controlled, retrospective pharmaco-epidemiological study in pancreas cancer

Immune-related toxicities are autoimmune conditions that can affect any organ in the body after ICI administration, with natural histories that are distinct from their de novo autoimmune disease counterparts

Toxicological screening is essential for pursuing natural bioactive compounds to be used in drug discovery

This process can be further exacerbated by neuroinflammatory processes, including chronically activated microglia and macrophages and the release of pro-inflammatory cytokines (e.g., TNF-, IL-1), ultimately leading to cell death (Ward et al., 2022)