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Native IGF-1 binds with high affinity to insulin-like growth factor binding proteins (IGFBPs), which sequester the peptide in circulation and substantially reduce its free bioavailable fraction

Rights and permissions About this article Cite this article Junnila, R., List, E., Berryman, D

[DOI] [PMC free article] [PubMed] [Google Scholar] 154.Giannopoulos-Dimitriou A, Saiti A, Petrou A, Vizirianakis IS, Fatouros DG

This imbalance primarily manifests as relative or absolute estrogen dominance coupled with enhanced progesterone action, which together establish the environmental foundation for abnormal proliferation of fibroid cells

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Bosia M., Spangaro M., Sapienza J., Martini F., Civardi S., Buonocore M., Bechi M., Lorenzi C., Cocchi F., Bianchi L., et al