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Description
Based on the role of estrogen metabolites in PH, we hypothesized that in early hypoxia, a significant reduction in CYP1A1 leads to a marked decrease in 2-ME2 levels, with 16a-OHE and 4-OHE being the predominant metabolites, notably higher in females compared with males, promoting SMC proliferation and vascular remodeling and contributing to a higher disease incidence in females
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47 MuddapuV
Early evaluation of the male should include a semen analysis
ABC transporters: ATP-binding cassette transporters
