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Studies have suggested that silymarin may enhance the synthesis of glutathione in the liver
Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

Additionally, regulatory frameworks should be updated to include specific guidelines for the evaluation and safe use of NBNs
With the rapid development of metabolomics, this method enables us to capture the simultaneous status of many small-molecule metabolites and uncovers that serine is closely related to various diseases, including infectious diseases, lung fibrosis, pulmonary hypertension, asthma and lung cancers

These antioxidant enzymes activated by Nrf2 act as cell defense system to detoxify NAPQI [35]
