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Oat peptides (DF-10), (HL-8) and (RW-9) have been shown to improve behavioural performance, reduce AChE activity, attenuate oxidative stress, and decrease the levels of inflammatory cytokines including TNF- , IL-6, and IL-1 in the brain of zebrafish exposed to scopolamine (110)

This peptide works through multiple mechanisms: Modulates gene expression involved in tissue remodeling Increases collagen and elastin synthesis Promotes angiogenesis during tissue repair Shifts gene expression toward the TGF- pathway to reduce inflammation and restore connective tissue The copper component is critical because it activates lysyl oxidase enzymes that crosslink collagen and elastin fibers

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There is limited data to indicate the minimum effective parenteral dose of GHK-Cu [11]