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This process leads to the accumulation of cholesterol in the endoplasmic reticulum and increased production of 24-hydroxycholesterol (24HC)
Vitamin D deficiency during lung development can lead to structural abnormalities and impaired lung function [342,343,344,345,346]
The Warburg effect indicates that cancer cells prefer to obtain energy through glycolysis rather than mitochondrial oxidative phosphorylation even when oxygen is sufficient, and the unrestrained proliferative nature of tumor cells as well as the hypoxic environment undoubtedly further exacerbates the accumulation of lactate in the TME [133]
LEE J, Clarkson PM
[PubMed] [Google Scholar] 106.Goncharova N.D., Vengerin A.A., Khavinson V.K., Lapin B.A
