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Chen et al, 1994

10.1177/10600280211073009 38 KrotzF.SohnH

FFA is known to be detoxified by multiple GSTUs in wild grasses and cereals ( At GSTU7 ( Figure 8A )

Mechanistically, glutamine is a major precursor for glutathione synthesis, therefore, limiting the utilization of glutamine by tumor cells leads to the reduction in GSH, inhibits the activity of sarcoplasmic reticulum Ca 2+ -ATPase (SERCA), and activates the NF-B signaling pathway, thereby promoting the expression of tumor PD-L1 and inactivating the co-cultured T cells