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[DOI] [PubMed] [Google Scholar] [99].Bourassa MW, Leskovjan AC, Tappero RV, Farquhar ER, Colton CA, Van Nostrand WE, et al

Innate immune responses to AAV vectors are primarily activated through the TLR9MyD88 signaling pathway, which induces the production of pro-inflammatory cytokines via nuclear factor B (NF-B) activation and the synthesis of type I interferons (IFNs) [110]

Thomas TP, Grisanti LA

UAs indirect impact on neutrophils Apart from direct stimulation of granulocytes, MSU crystals can also modulate the immune microenvironment indirectly by affecting other immune cells