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some of them interact directly with NRF2, while others interact indirectly with it and directly with KEAP1 [169]

Some experience minimal soreness at the injection site, which usually resolves quickly

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Lower tirzepatide doses (510mg weekly) reduce GI side effect burden while still providing meaningful appetite suppression, allowing researchers to maintain protocol adherence without the nausea and vomiting that causes 1015% of subjects to discontinue at higher doses