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The functional activity of several proteins requires the presence of certain prosthetic groups covalently bound to the polypeptide chain
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A Pilot Study of Neurofeedback for Chronic PTSD

To distinguish a transcription dependent from a structural role of HIF1 (e.g., by sequestering its dimerization partners Arnt and Arnt2), we used HIF1C (Jiang et al , 1997), a deletion mutant with impaired transcriptional activity (Fig EV4O)

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