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As inflammation emerges as a critical therapeutic target, ongoing research aims to unravel its underlying mechanisms

A history of hypothyroidism and the use of thyroid replacement medication should not exclude participation, as long as the amount of thyroid medication a participant is taking is appropriate to what they need

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this, in turn, leads to accentuated elevations in blood concentrations of tHcy and MMA, and exacerbation of neurological sequelae due to vitamin B-12 deficiency in the brain and peripheral nervous system To test these and other predictions, in addition to human studies, it will be important to develop better animal models with closer similarity to the physiologic and clinical features of vitamin B-12 deficiency than rodent models currently provide

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