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Defining the human copper proteome and analysis of its expression variation in cancers

6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway

These findings are consistent with those for other antioxidant enzymes: for example, lack of peroxiredoxin 3, a mitochondrially localized antioxidant enzyme, also augments apoptotic signaling in some cell types (60)

doi: 10.1186/s41927-024-00450-2

Therefore, further studies in humans are needed in order to evaluate the efficacy of these phytochemicals and their feasibility as a natural substitute for pharmaceutical agents, many of which are associated with adverse side effects