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Viral infections are associated with reduced GSH levels, which cause a cellular redox imbalance and activate a vicious cycle of reduced host defenses, leading to a severe imbalance in the intracellular microenvironment, and adjunctive antioxidant treatment may improve the outcomes of antiviral therapies (77)

Changes in 14 metabolites mainly involved in GSH, amino acids, nucleotides and choline metabolism (Supplementary Figure S2AC) correlated with resistance in both cell line pairs (Figure 1d

IGF-1 is mainly produced by microglia, which is elevated during the inflammatory process [138, 139]