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Obeid, R., Andrs, E., eka, R., Hooshmand, B., Guant-Rodriguez, R

Mechanisms of Vitamin B12 deficiency with Metformin Use: It has been proposed that metformin reduces Vitamin B12 absorption by following mechanisms Alterations in small bowel motility which stimulates bacterial overgrowth and consequential vitamin B12 deficiency Competitive inhibition or inactivation of vitamin B12 absorption Alterations in intrinsic factor (IF) levels and interaction with the cubulin endocytic receptor Inhibition of the calcium dependent absorption of the vitamin B12-IF complex at the terminal ileum Reference: Fatima, S., Noor, S

I also find a small dose of Doxylamine helps hugely and take an eighth of a 50mg dose when I need to.I hope things improve for you soon, my body seems at last to be settling down and I do now feel better than I have for a long time

[1] [2] Studies have found that correcting B12 deficiency can lead to improvement in ulcer frequency and severity in affected patients

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