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In young and aged rats, treadmill exercise for a duration of 6 weeks led to increased SIRT1 activity, NAMPT and NAD + levels, and decreased mitochondrial generation of ROS 302
[DOI] [PubMed] [Google Scholar] Vaupel JW
168 As physical activity continues, the muscles may become less effective at stabilizing the knee, leading to greater reliance on the ACL and increased risk of damage
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