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As with nearly any emerging field of study, there are methodological inconsistencies which can significantly impact measures of analyte(s)

Glucose accumulation also promotes cholesterol (TC), triglyceride (TG), lipid synthesis-regulating transcription factor upregulation (SREBP), and LDL-C levels, and decreases high-density lipoprotein (HDL-C) levels, which promotes the buildup of fats in the liver and kidney tissues, resulting in kidney damage

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It plays a fundamental role in gene signaling related to repair, regeneration, and collagen production