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In the acute phase, symptoms include euphoria, anxiety, paranoia, and psychomotor agitation, which are primarily caused by the short-term overactivation of neurotransmitter systems ( 2.3.1 Cognitive impairment METH abuse significantly impairs cognitive function by targeting key brain regions ( 2.3.2 Psychiatric symptoms METH abuse disrupts the functionality of various brain regions, including the prefrontal cortex, nucleus accumbens, and thalamus, leading to significant psychiatric disturbances ( 2.3.3 Motor dysfunction Motor dysfunction caused by METH abuse is commonly characterized by parkinsonian-like symptoms, including tremors, bradykinesia, and rigidity ( 2.4 Auxiliary examinations Auxiliary examinations, particularly neuroimaging and neurochemical analyses, play a crucial role in identifying functional and structural changes in the nervous system caused by METH abuse

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doi: 10.1172/JCI110170

In exercise science, achieving High certainty is inherently challenging because double-blinding (blinding participants to the intervention) is impossible, which automatically triggers specific risk-of-bias penalties in tools like AMSTAR-2 and GRADE