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Subcellular distribution of CoQ 9 is altered, which may explain the lowered oxygen consumption and ATP production phenotype of heterozygous Mclk1 +/ mitochondria [199,200]

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Ann Nutr Metab 67(1):112 Dos Santos T, Siebert C, de Oliveira M, Manfredini V, Wyse AJC (2019) Chronic mild Hyperhomocysteinemia impairs energy metabolism, promotes DNA damage and induces a Nrf2 response to oxidative stress in rats brain

The 2 primary functions of this pathway are (1) the generation of NADPH for use in other reductive biosynthetic (anabolic) pathways and (2) to convert glucose carbons into ribose 5-phosphate (R5P) for the synthesis of the nucleotides and nucleic acids

Additionally, phytobiotics like polyphenols, while beneficial for their antioxidant properties, can inhibit digestive enzymes, reducing nutrient digestibility in later stages