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However, they may undergo slow hydrolysis in circulation, risking premature payload release and off-target toxicity

Many doctors have also never heard of it either, so raising the profile of this condition is vital

However, the chemical stability of ether bonds, which requires harsh conditions for cleavage, limits their metabolic degradation and may increase cytotoxicity risks [105]

The amino group acts as a base and accepts a proton, while the carboxyl group acts as an acid and donates a proton

These include ATP-citrate lyase (ACLY) [102], fatty acid synthetase (FASN) [103], and carnitine palmitoyltransferase 1 (CPT1) [104, 105], among others