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Future patent activity will likely need to shift toward formulation engineering, targeted delivery to reproductive tissues, and the development of semi-synthetic derivatives aimed at overcoming luteolins pharmacokinetic limitations
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Multi-organ viral tropism predominantly in cells expressing ACE2, TMPRSS2, or both has been reported 82,83
Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice
