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Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice

USA 113 , E6271e6280 (2016)

[1] [2] When neurological symptoms are present such as paraesthesia, numbness, balance problems, or cognitive changesmore aggressive treatment is required

doi: 10.1021/acs.jmedchem.0c01914 135 MengQSuCH

in particular, data from HNE cells cultured at ALI have been shown to correlate strongly with in vivo clinical responses to CFTR modulators, serving as an effective pre-clinical tool to predict patient-specific drug efficacy