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Under type 2 (T2) conditions (IL-13 stimulation), human airway epithelial cells (HAECs) generate oxidized phospholipids under control of the 15 lipoxygenase 1 (15LO1) enzyme and its binding with phosphatidylethanolamine-binding protein 1 (PEBP1) (6)

A study by Guerra et al followed 1400 adults in the Tucson Epidemiologic Study of Airway Obstructive Disease (TESAOD) who had no airflow obstruction or asthma at enrollment

[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Battino M, Bullon P, Wilson M, Newman H