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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

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For short trips, reconstituted peptide can be kept at room temperature for up to 72 hours without significant degradation, though refrigeration is always preferred

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