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[DOI] [PMC free article] [PubMed] [Google Scholar] 438.Zhong Q.X., Zhang L.H
Plasmids CRISPRCas9 sgRNA vectors targeting 2M and ABHD11 were previously generated by the laboratory 16
The authors used differentiated dopaminergic neurons (DN) from patients-iPSC, which are involved in the pathology of LS, and they observed that SURF1 mutant DNs showed a reduced number of neurons, as well as defects in neuronal maturation
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On the other hand, in case of excessive distress, cells are exposed to high levels of ROS which can cause neuroinflammation, damage to the blood-brain barrier (BBB) and impairment to astrocyte crosstalk leading to ASD (Russo et al., 2018)
