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In theory, due to the complex heterogeneous bacterial population consisting of growing and non-growing persister cells, 24,484,485 a drug combination approach targeting these two bacterial populations would be important to cure persistent infections, according to the Yin-Yang model

doi: 10.1074/jbc.M109.036871 210 OnkokesungN.ReicheltM.van DoornA.SchuurinkR

5 UGT1A1 is a major enzyme involved in this process

Alternatively, safety switches can be added to the CAR structure to effectively block cytokine storms, thereby improving the safety of CAR-T clinical treatment

In contrast, marked up-regulation of several GST s was observed in most of the datasets