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To provide quantitative data on the possible role of HNE in oxidative genotoxicity, we applied an accurate HPLC-MS approach to the quantification of HNE adducts to DNA and of HNE conjugates to glutathione (HNE-GSH), the product of the major detoxification pathway of HNE in cells

Multivariable logistic regression analyses and thematic synthesis were undertaken

Fifty-two patients were previously treated with sildenafil 100 mg (30.6%), 6 with vardenafil 20mg (3.5%), 56 with tadalafil 20mg (32.9%), and 56 with avanafil 200mg (32.9%)