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NPs should take a proactive approach to prevent it by monitoring vitamin B12 or MMA concentrations during long-term metformin treatment and prescribing replacement therapy when low levels of B12 or increased levels of MMA are found
Functional Vitamin B2 Deficiency in Autism
[24] A study in a pregnant white non-diabetic population in England, found that for every 1% increase in BMI, there was 0.6% decrease in circulating B 12
The animal data backs this up in a striking way: a single dose lowered serotonin production in the brain, while long-term use raised it
doi: 10.1155/2020/6805354
