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Antibiotics (Basel) 2021

1.7 Fluid Ounces
Second, the therapeutic indication (e.g., cardiovascular, central nervous system (CNS), oncology, and rare/orphan disease) will dictate whether additional assessments and considerations are necessary to better understand doserelated efficacy and toxicity in target organs to estimate a safety margin

Psychiatry 79 , 251257 (2016)

Verdaasdonk, J